朱敏生博士实验室

朱敏生 PhD

遗传学教授、博士生导师

电话

办公室：58641529

实验室：58641526

电子邮件 ：zms@nicemice.cn　　zhums@nicemice.cn

研究兴趣：主要为通过小鼠遗传学方法研究细胞运动和平滑肌收缩调控的分子机制。

代表论文：

1. Pan Y, Chen HQ, Shen Y, Chen C, Wang G, Wang XC, Gao X, Zhu MS. Curcumin attenuates dystrophic pathology in mdx mice through inhibiting NF-kappaB activation. Neuromuscular Disorders. (revised)

2.Ma CL, Yao K, Xu J, Sun H, Zhu MS. Induction of SARS-CoV mucleocapsid protein specific immune response by use of DNA vaccination followed by adenovirus boosting in BALB/c mice. Intervirology. 2006, in press.

3.Wei DM, Gao Y, Cao XY, Zhu NC, Liang JF, Xie WP, Zhen MY, Zhu MS. Soluble multimer of recombinant endostatin expressed in E.Coli has anti-angiogenesis activity. Biochem Biophys Res Commun. 2006 ;345(4):1398-40

4.Yang CX, Chen HQ, Chen C, Yu WP, Zhang WC, Peng YJ, He WQ, Wei DM, Gao X and Zhu MS. Microfilament binding properties of N-terminal extension of long isoform of smooth muscle light chain kinase. Cell Res. 2006;16:367-376.

5. Yang CX, Wei DM, Chen C, Yu WP and Zhu MS. 5DFRXXL region of long myosin light chain kinase causes F-actin bundle formation. Chinese Science Bulletin 2005;50(18):2044-2050

6. Zhu MS SARS immunity and vaccination Cellular and Molecular Immunology 2004; 1(3):193-198

7. Zhu MS, Pan Y, Chen HQ, Shen Y, Wang XC, Sun YJ, Tao KH. Induction of SARS-nucleoprotein-specific immune response by use of DNA vaccine. Immunol Lett. 2004 ;92(3):237-43.

8. Smith L, Parizi-Robinson M, Zhu MS （equal）, Zhi G, Fukui R, Kamm KE, Stull JT. Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J Biol Chem. 2002 ;277(38):35597-604.

9. Zhu MS, Liu DG, Cheng HQ, Xu XY, Li ZP. Expression of exogenous NF-IL6 induces apoptosis in Sp2/0-Ag14 myeloma cells. DNA Cell Biol. 1997 ;16(2):127-35.

10. Zhu MS, Fan YH, Shen Y, Wang G, Pan Y. Abnormal expression of inducible oxide synthase in Duchenne muscular dystrophy muscles. Chinese Sci Bulletin 1998;43:860

实验室成员：

技术员 ：陈晨

研究生 ：张文程、彭亚静、何伟奇、高嵩

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