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朱敏生
PhD
遗传学教授、博士生导师
电话
办公室：58641529
实验室：58641526
电子邮件
：
zhums@nju.edu.cn; zhums@nicemice.cn
研究兴趣：
通过建立转基因和基因敲除小鼠，在系统生物学水平研究：1）平滑肌收缩的分子调控机制；2）神经发育与细胞运动的信号网络调控。
近期论文：(* corresponding author)
1. He WQ， Peng YJ, Zhang WC, Lv N, Tang J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull JT, Gao X, Zhu MS* Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 2008; in press.
2. Zhang WC, Peng YJ, He WQ, Chen C, Zhi G, Chen HQ, Zhu MS* Identification and Functional Characterization of an Aggregation Domain in Long Myosin Light Chain Kinase. FEBS J 2008;275:2489-2500
3. Pan Y, Chen C, Shen Y, Zhu CH, Wang G, Wang XC, Chen HQ and Zhu MS*??? Curcumin Alleviates Dystrophic Muscle Pathology in mdx Mice. Mol & Cells 2008; in press
4.Ma CL, Yao K, Xu J, Sun H, Zhu MS. Induction of SARS-CoV mucleocapsid protein specific immune response by use of DNA vaccination followed by adenovirus boosting in BALB/c mice. Intervirology. 2006;49(5):307-18.
5. Wei DM, Gao Y, Cao XY, Zhu NC, Liang JF, Xie WP, Zhen MY, Zhu MS*. Soluble multimer of recombinant endostatin expressed in E.Coli has anti-angiogenesis activity. Biochem Biophys Res Commun. 2006 ;345(4):1398-40
6. Yang CX, Chen HQ, Chen C, Yu WP, Zhang WC, Peng YJ, He WQ, Wei DM, Gao X and Zhu MS*. Microfilament binding properties of N-terminal extension of long isoform of smooth muscle light chain kinase. Cell Res. 2006;16:367-376.
7. Yang CX, Wei DM, Chen C, Yu WP and Zhu MS*. 5DFRXXL region of long myosin light chain kinase causes F-actin bundle formation. Chinese Science Bulletin 2005;50(18):2044-2050
8. Zhu MS* SARS immunity and vaccination Cellular and Molecular Immunology 2004; 1(3):193-198
9. Zhu MS*, Pan Y, Chen HQ, Shen Y, Wang XC, Sun YJ, Tao KH. Induction of SARS-nucleoprotein-specific immune response by use of DNA vaccine. Immunol Lett. 2004 ;92(3):237-43.
10. Smith L, Parizi-Robinson M, Zhu MS （equal）, Zhi G, Fukui R, Kamm KE, Stull JT. Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J Biol Chem. 2002 ;277(38):35597-604.
实验室成员：
技术员
：余芝青
在读研究生（硕博士连读）：张文程、彭亚静、何伟奇、张成海、乔艳宁、陈晨、高云倩
合作单位研究生：吕宁、范迟
大学生创新计划人员：王佩、陶陶
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