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宁文
PhD
教授
电话
办公室：58641508
实验室：58641526
电子邮件 ：
ningwen@nicemice.cn
研究方向：细胞生物学、发育生物学、遗传学
主要学术成果：
1)
早期反应基因EGR-1在吸烟引起慢性阻塞性肺疾病(COPD)的分子机制的研究。2）利用Fstl1基因敲除小鼠，研究早期肺发育的过程和机制，并建立相关肺疾病（如：肺纤维化-IPF）的动物模型。
论文著作：
1. Ning
W, Li CJ, Feghali-Bostwick CA,
Matthay MA Choi AM.
（2007）MAPK-EGR-1-HSP70 pathway
regulates cigarette smoke induced chemokine release in
human lung fibroblasts.Am J Physiol
Lung Cell Mol Physiol. 292(5):L1297-303
2.
Ning W,
Dong Y, Sun J, Li CJ, Feghali-Bostwick CA,
Matthay MA Choi AM.（2007）
Cigarette Smoke Stimulates Matrix Metalloproteinase
Activity via EGR-1 in Human Lung Fibroblasts. Am J
Respir. Cell Mol. Biol. 36(4):480-90.
3. Ning
W, Peters DG, Chu TJ, Li C, Choi
AM.（2006）Comparative SAGE Analysis of the Response to
Hypoxia in Human Pulmonary and Aortic Endothelial Cells.
Physiol Genomics.
26(2):99-108
4.
Ning W,
Choi AM Li C. （2005）Carbon monoxide inhibits
IL-17-induced IL-6 production through the MAPK pathway
in human pulmonary epithelial cells. Am J Physiol
Lung Cell Mol Physiol. 289(2):L268-73.
5. Ning
W,
Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP,
Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ,
Watkins SC, Pilewski JK, Sciurba FC, Peters DG, Hogg JC,
Choi AM. （2004） Comprehensive gene expression profiles
reveal pathways related to the pathogenesis of chronic
obstructive pulmonary disease.Proc Natl Acad Sci U S
A. 101(41):14895-900.
6.
Ning W,
Chu TJ, Li CJ, Choi AM, Peters DG. Genome-wide analysis
of the endothelial transcriptome under short-term
chronic hypoxia. Physiol Genomics. 2004
;18(1):70-8.
7.
Ning W,
Song R, Li C, Park E, Mohsenin A, Choi, Choi ME.
TGF-beta1 stimulates HO-1 via the p38 mitogen-activated
protein kinase in A549 pulmonary epithelial cells. Am
J Physiol Lung Cell Mol Physiol. 2002
;283(5):L1094-102.
实验室技术员:孙静霞
实验室成员：懂莺莺，耿燕，乔龙，耿慧霞，戴进，黄际河。
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