何玉龙  PhD

遗传学，教授，博士生导师

电话

办公室：58641512

实验室：58641522

电子邮件 ：

yhe20005@yahoo.com

yulong.he@nicemice.cn

研究兴趣：

血管新生 (angiogenesis) 与淋巴管新生 (lymphangiogenesis) 的分子调控，以及肿瘤转移的分子机制。

代表论文：

1. Tammela T, He Y(co-first author), Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K. Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins. Circulation Research 2007 May 3; [Epub ahead of print]. IF: 9.408

2. He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. VEGFR-3 mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65:4739-46(2005). IF: 8.649

3. He Y, Rajantie I, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K.    Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis . Cancer Res 64:3737-40 (2004). IF: 8.649

4. He Y, Karpanen T and Alitalo K. Role of lymphangiogenic factors in lymphatic tumor metastasis. Biochim Biophys Acta 1654:3-12 (2004). IF: 8.395

5. He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94:785-7 (2002). IF: 13.844

6. He Y, Smith SK, Day KA, Clark D, Licence DR, Charnock-Jones DS. Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity.  Mol Endocrinol 13:537-545 (1999). IF: 5.708

实验室成员：

技术员： 曹燕兰

研究生： 焦吉祥、周飞、王博、张禄卿、黄惠莲

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